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http://hdl.handle.net/2445/209323| Title: | Chemical rewiring of ubiquitination by degraders and their selectivity routes |
| Author: | Whelan, Rory Mayor Ruiz, Cristina |
| Keywords: | Disseny de medicaments Modificació química de les proteïnes Drug design Chemical modification of proteins |
| Issue Date: | 16-Feb-2024 |
| Publisher: | Springer Nature |
| Abstract: | Ubiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of ‘degraders’ for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41594-024-01215-8 |
| It is part of: | Nature Structural & Molecular Biology, 2024, vol. 31, p. 205-207 |
| URI: | http://hdl.handle.net/2445/209323 |
| Related resource: | https://doi.org/10.1038/s41594-024-01215-8 |
| ISSN: | 1545-9985 |
| Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Nat Struct Mol Biol_Whelan_Mayor-Ruiz_2024.pdf | 850.03 kB | Adobe PDF | View/Open Request a copy |
Document embargat fins el
16-8-2024
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