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Title: Low transmission of SARS-CoV-2 derived from children in family clusters: An observational study of family households in the Barcelona Metropolitan Area, Spain
Author: Melé Casas, Maria
Launes Montaña, Cristian
Fernández de Sevilla Estrach, Mariona
Hernández García, María
Pons Tomàs, Gemma
Bassat Orellana, Quique
Fumadó, Victoria
Fortuny Guasch, Claudia
Garcia Miquel, Aleix
Bonet Carné, Elisenda
Prats, Clara
Ajanovic, Sara
Cubells, Marta
Claverol, Joana
Penela Sánchez, Daniel
Jou, Cristina
Arias, Sara
Balanza, Núria
Baro, Bàrbara
Millat-Martínez, Pere
Alonso Muñoz, Sergio
Álvarez Lacalle, Enrique
Català, Martí
Cuadras, Daniel
Muñoz-Almagro, Carmen
Gratacós Solsona, Eduard
Jordán García, Iolanda
García García, Juan José
Keywords: Infeccions
Issue Date: 17-Nov-2022
Publisher: Public Library of Science (PLoS)
Abstract: Background: Family clusters offer a good opportunity to study viral transmission in a stable setting. We aimed to analyze the specific role of children in transmission of SARS-CoV-2 within households. Methods: A prospective, longitudinal, observational study, including children with documented acute SARS-CoV-2 infection attending 22 summer-schools in Barcelona, Spain, was performed. Moreover, other patients and families coming from other school-like environments that voluntarily accessed the study were also studied. A longitudinal follow-up (5 weeks) of the family clusters was conducted to determine whether the children considered to be primary cases were able to transmit the virus to other family members. The household reproduction number (Re*) and the secondary attack rate (SAR) were calculated. Results: 1905 children from the summer schools were screened for SARS-CoV-2 infection and 22 (1.15%) tested positive. Moreover, 32 additional children accessed the study voluntarily. Of these, 37 children and their 26 households were studied completely. In half of the cases (13/26), the primary case was considered to be a child and secondary transmission to other members of the household was observed in 3/13, with a SAR of 14.2% and a Re* of 0.46. Conversely, the SAR of adult primary cases was 72.2% including the kids that gave rise to the contact tracing study, and 61.5% without them, and the estimated Re* was 2.6. In 4/13 of the paediatric primary cases (30.0%), nasopharyngeal PCR was persistently positive > 1 week after diagnosis, and 3/4 of these children infected another family member (p<0.01). Conclusions: Children may not be the main drivers of the infection in household transmission clusters in the study population. A prolonged positive PCR could be associated with higher transmissibility.
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It is part of: PLoS One, 2022, vol. 17, num.11
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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