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Title: Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
Author: Ribasés Haro, Marta
Mitjans Niubó, Marina
Hartman, C.A.
Soler Artigas, María
Demontis, D.
Larsson, H.
Ramos-Quiroga, Josep Antoni
Kuntsi, J.
Faraone, S.V.
Børglum, A.D.
Reif, A.
Franke, B.
Cormand Rifà, Bru
Keywords: Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Attention deficit disorder with hyperactivity in adults
Attention deficit disorder with hyperactivity in children
Issue Date: Oct-2023
Publisher: Elsevier
Abstract: Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.
Note: Reproducció del document publicat a:
It is part of: Neuroscience and Biobehavioral Reviews, 2023, vol. 153, p. 1-20
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ISSN: 0149-7634
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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