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http://hdl.handle.net/2445/211324
Title: | Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2 |
Author: | Pérez Jurado, Luis A. Cáceres, Alejandro Balagué Dobón, Laura Esko, Tonu López de Heredia, Miguel Quintela, Inés Cruz, Raquel Lapunzina, Pablo Carracedo, Ángel SCOURGE Cohort Group González, Juan R. |
Keywords: | COVID-19 Anomalies cromosòmiques COVID-19 Chromosome abnormalities |
Issue Date: | 19-Feb-2024 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s42003-024-05805-6 |
It is part of: | Communications Biology, 2024, vol. 7, num. 1 |
URI: | http://hdl.handle.net/2445/211324 |
Related resource: | https://doi.org/10.1038/s42003-024-05805-6 |
ISSN: | 2399-3642 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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