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DC Field | Value | Language |
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dc.contributor.author | Fico, Giovanna | - |
dc.contributor.author | Janiri, Delfina | - |
dc.contributor.author | Pinna, Marco | - |
dc.contributor.author | Sagué Vilavella, Maria | - |
dc.contributor.author | Giménez Palomo, Anna | - |
dc.contributor.author | Oliva, Vincenzo | - |
dc.contributor.author | De Prisco, Michele | - |
dc.contributor.author | Guzmán Cortez, Pablo | - |
dc.contributor.author | Anmella, Gerard | - |
dc.contributor.author | Gonda, Xenia | - |
dc.contributor.author | Sani, Gabriele | - |
dc.contributor.author | Tondo, Leonardo | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.contributor.author | Murru, Andrea | - |
dc.date.accessioned | 2024-06-21T17:20:23Z | - |
dc.date.available | 2024-06-21T17:20:23Z | - |
dc.date.issued | 2023-02-15 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.uri | http://hdl.handle.net/2445/213514 | - |
dc.description.abstract | Background: Affective temperaments show potential for aggressive behavior (AB) preventive strategies in bipolar disorder (BD). We aim to define intra-diagnostic subgroups of patients with BD based on homogeneous behaviors related to AB. Subsequently, to assess whether affective temperament dimensions may contribute to the presence and severity of AB. Methods: Patients with BD were recruited. AB was evaluated through the modified overt aggression scale (MOAS); affective temperaments were assessed with the TEMPS-A. A cluster analysis was conducted based on TEMPS-A and MOAS scores. Stepwise backward logistic regression models were used to identify the predictive factors of cluster membership. Results: 799 patients with BD were enrolled. Three clusters were determined: non-aggressive (55.5 %), self-aggressive (18 %), and hetero-aggressive (26.5 %). Depressive, irritable, and anxious temperament scores significantly increased from the non-aggressive (lower) to the self-aggressive (intermediate) and the hetero-aggressive group (highest). A positive history of a suicide attempt (B = 5.131; OR = 169.2, 95 % CI 75.9; 377) and rapid cycling (B = -0.97; OR = 0.40, 95 % CI 0.17; 0.95) predicted self-aggressive cluster membership. Atypical antipsychotics (B = 1.19; OR = 3.28, 95 % CI 2.13; 5.06) or SNRI treatment (B = 1.09; OR = 3, 95 % CI 1.57; 5.71), psychotic symptoms (B = 0.73; OR = 2.09, 95 % CI 1.34; 3.26), and history of a suicide attempt (B = -1.56; OR = 0.20, 95 % CI 0.11; 0.38) predicted hetero-aggressive cluster membership. Limitations: Recall bias might have affected the recollection of AB. Conclusions: Clinical factors orientate the prevention of different ABs in BD. Affective temperaments might play a role in preventing AB since patients with more pronounced affective temperaments might have an increased risk of showing AB, in particular hetero-AB. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.jad.2022.11.084 | - |
dc.relation.ispartof | Journal of Affective Disorders, 2023, vol. 323, p. 327-335 | - |
dc.relation.uri | https://doi.org/10.1016/j.jad.2022.11.084 | - |
dc.rights | cc-by (c) Fico, Giovanna et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | * |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Agressivitat | - |
dc.subject.classification | Assaigs clínics | - |
dc.subject.classification | Temperament | - |
dc.subject.classification | Anàlisi de conglomerats | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.other | Aggressiveness | - |
dc.subject.other | Clinical trials | - |
dc.subject.other | Temperament | - |
dc.subject.other | Cluster analysis | - |
dc.subject.other | Manic-depressive illness | - |
dc.title | Affective temperaments mediate aggressive dimensions in bipolar disorders: A cluster analysis from a large, cross-sectional, international study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 728200 | - |
dc.date.updated | 2024-06-21T17:20:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36470551 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) |
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