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Title: | Affective temperaments mediate aggressive dimensions in bipolar disorders: A cluster analysis from a large, cross-sectional, international study |
Author: | Fico, Giovanna Janiri, Delfina Pinna, Marco Sagué Vilavella, Maria Giménez Palomo, Anna Oliva, Vincenzo De Prisco, Michele Guzmán Cortez, Pablo Anmella, Gerard Gonda, Xenia Sani, Gabriele Tondo, Leonardo Vieta i Pascual, Eduard, 1963- Murru, Andrea |
Keywords: | Agressivitat Assaigs clínics Temperament Anàlisi de conglomerats Trastorn bipolar Aggressiveness Clinical trials Temperament Cluster analysis Manic-depressive illness |
Issue Date: | 15-Feb-2023 |
Publisher: | Elsevier B.V. |
Abstract: | Background: Affective temperaments show potential for aggressive behavior (AB) preventive strategies in bipolar disorder (BD). We aim to define intra-diagnostic subgroups of patients with BD based on homogeneous behaviors related to AB. Subsequently, to assess whether affective temperament dimensions may contribute to the presence and severity of AB. Methods: Patients with BD were recruited. AB was evaluated through the modified overt aggression scale (MOAS); affective temperaments were assessed with the TEMPS-A. A cluster analysis was conducted based on TEMPS-A and MOAS scores. Stepwise backward logistic regression models were used to identify the predictive factors of cluster membership. Results: 799 patients with BD were enrolled. Three clusters were determined: non-aggressive (55.5 %), self-aggressive (18 %), and hetero-aggressive (26.5 %). Depressive, irritable, and anxious temperament scores significantly increased from the non-aggressive (lower) to the self-aggressive (intermediate) and the hetero-aggressive group (highest). A positive history of a suicide attempt (B = 5.131; OR = 169.2, 95 % CI 75.9; 377) and rapid cycling (B = -0.97; OR = 0.40, 95 % CI 0.17; 0.95) predicted self-aggressive cluster membership. Atypical antipsychotics (B = 1.19; OR = 3.28, 95 % CI 2.13; 5.06) or SNRI treatment (B = 1.09; OR = 3, 95 % CI 1.57; 5.71), psychotic symptoms (B = 0.73; OR = 2.09, 95 % CI 1.34; 3.26), and history of a suicide attempt (B = -1.56; OR = 0.20, 95 % CI 0.11; 0.38) predicted hetero-aggressive cluster membership. Limitations: Recall bias might have affected the recollection of AB. Conclusions: Clinical factors orientate the prevention of different ABs in BD. Affective temperaments might play a role in preventing AB since patients with more pronounced affective temperaments might have an increased risk of showing AB, in particular hetero-AB. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jad.2022.11.084 |
It is part of: | Journal of Affective Disorders, 2023, vol. 323, p. 327-335 |
URI: | http://hdl.handle.net/2445/213514 |
Related resource: | https://doi.org/10.1016/j.jad.2022.11.084 |
ISSN: | 0165-0327 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) |
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