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DC Field | Value | Language |
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dc.contributor.author | Agustí García-Navarro, Àlvar | - |
dc.contributor.author | Melén, Erik | - |
dc.contributor.author | DeMeo, Dawn L. | - |
dc.contributor.author | Breyer-Kohansal, Robab | - |
dc.contributor.author | Faner, Rosa | - |
dc.date.accessioned | 2024-07-25T11:29:41Z | - |
dc.date.available | 2024-07-25T11:29:41Z | - |
dc.date.issued | 2022-04-12 | - |
dc.identifier.issn | 2213-2600 | - |
dc.identifier.uri | http://hdl.handle.net/2445/214722 | - |
dc.description.abstract | The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted disease caused by tobacco</p><p>smoking in genetically susceptible individuals has been challenged by recent research findings. COPD can instead be</p><p>understood as the potential end result of the accumulation of gene–environment interactions encountered by an</p><p>individual over the lifetime. Integration of a time axis in pathogenic models of COPD is necessary because the</p><p>biological responses to and clinical consequences of different exposures might vary according to the age of an</p><p>individual at which a given gene–environment interaction occurs, as well as to the cumulative history of previous</p><p>gene–environment interactions. Future research should aim to understand the effects of dynamic interactions</p><p>between genes (G) and the environment (E) by integrating information from basic omics (eg, genomics, epigenomics,</p><p>proteomics) and clinical omics (eg, phenomics, physiomics, radiomics) with exposures (the exposome) over time</p><p>(T)—an approach that we refer to as GETomics. In the context of this approach, we argue that COPD should be</p><p>viewed not as a single disease, but as a clinical syndrome characterised by a recognisable pattern of chronic symptoms</p><p>and structural or functional impairments due to gene–environment interactions across the lifespan that influence</p><p>normal lung development and ageing. | - |
dc.format.extent | 41 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/S2213-2600(21)00555-5 | - |
dc.relation.ispartof | The Lancet Respiratory Medicine, 2022, vol. 10, num.5, p. 512-524 | - |
dc.relation.uri | https://doi.org/10.1016/S2213-2600(21)00555-5 | - |
dc.rights | cc-by-nc-nd (c) Elsevier Ltd, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Influència del medi ambient en l'home | - |
dc.subject.classification | Hàbit de fumar | - |
dc.subject.classification | Símptomes | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Genetics | - |
dc.subject.other | Environmental effects on human beings | - |
dc.subject.other | Smoking | - |
dc.subject.other | Symptoms | - |
dc.title | Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 724830 | - |
dc.date.updated | 2024-07-25T11:29:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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