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Title: | Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan |
Author: | Agustí García-Navarro, Àlvar Melén, Erik DeMeo, Dawn L. Breyer-Kohansal, Robab Faner, Rosa |
Keywords: | Malalties pulmonars obstructives cròniques Genètica Influència del medi ambient en l'home Hàbit de fumar Símptomes Chronic obstructive pulmonary diseases Genetics Environmental effects on human beings Smoking Symptoms |
Issue Date: | 12-Apr-2022 |
Publisher: | Elsevier Ltd |
Abstract: | The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted disease caused by tobacco</p><p>smoking in genetically susceptible individuals has been challenged by recent research findings. COPD can instead be</p><p>understood as the potential end result of the accumulation of gene–environment interactions encountered by an</p><p>individual over the lifetime. Integration of a time axis in pathogenic models of COPD is necessary because the</p><p>biological responses to and clinical consequences of different exposures might vary according to the age of an</p><p>individual at which a given gene–environment interaction occurs, as well as to the cumulative history of previous</p><p>gene–environment interactions. Future research should aim to understand the effects of dynamic interactions</p><p>between genes (G) and the environment (E) by integrating information from basic omics (eg, genomics, epigenomics,</p><p>proteomics) and clinical omics (eg, phenomics, physiomics, radiomics) with exposures (the exposome) over time</p><p>(T)—an approach that we refer to as GETomics. In the context of this approach, we argue that COPD should be</p><p>viewed not as a single disease, but as a clinical syndrome characterised by a recognisable pattern of chronic symptoms</p><p>and structural or functional impairments due to gene–environment interactions across the lifespan that influence</p><p>normal lung development and ageing. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/S2213-2600(21)00555-5 |
It is part of: | The Lancet Respiratory Medicine, 2022, vol. 10, num.5, p. 512-524 |
URI: | http://hdl.handle.net/2445/214722 |
Related resource: | https://doi.org/10.1016/S2213-2600(21)00555-5 |
ISSN: | 2213-2600 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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