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http://hdl.handle.net/2445/214723
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DC Field | Value | Language |
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dc.contributor.author | Martino, David J. | - |
dc.contributor.author | Bui, Dinh S. | - |
dc.contributor.author | Li, Shuai | - |
dc.contributor.author | Idrose, Sabrina | - |
dc.contributor.author | Perret, Jennifer | - |
dc.contributor.author | Lowe, Adrian J. | - |
dc.contributor.author | Lodge, Caroline J. | - |
dc.contributor.author | Bowatte, Gayan | - |
dc.contributor.author | Moodley, Yuben | - |
dc.contributor.author | Thomas, Paul S. | - |
dc.contributor.author | Zosky, Graeme | - |
dc.contributor.author | Zosky, Graeme | - |
dc.contributor.author | Holloway, John W. | - |
dc.contributor.author | Svanes, Cecilie | - |
dc.contributor.author | Faner, Rosa | - |
dc.contributor.author | Walters, Eugene H. | - |
dc.contributor.author | Dharmage, Shyamali C. | - |
dc.date.accessioned | 2024-07-25T11:29:46Z | - |
dc.date.available | 2024-07-25T11:29:46Z | - |
dc.date.issued | 2023-11-15 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | http://hdl.handle.net/2445/214723 | - |
dc.description.abstract | <p>Understanding the molecular mechanisms of lung function trajectories that progress to chronic obstructive pulmonary disease (COPD) (pre-COPD trajectories), especially those with a rapidly declining phenotype, should inform preventive interventions. The Tasmanian Longitudinal Health Study (TAHS) previously defined life-course lung function trajectories by serial spirometry in a cohort of all seven-year-old school children in the state of Tasmania recruited in 1968 and followed up to age 53 years (1). Of the six pre-bronchodilator FEV1 lifetime trajectories identified, three collectively accounted for 75% of chronic obstructive pulmonary disease (COPD) prevalence at age 53 years (2). These high-risk trajectories were: 1) early below average lung function (with usual rate of subsequent decline), 2) persistently low, and 3) early below average lung function with accelerated decline. The TAHS cohort provides a unique opportunity to investigate molecular factors associated with disadvantaged trajectories, and we conducted a pilot study in this cohort to characterize associations with COPD high-risk trajectories to inform more extensive longitudinal studies in the future.</p> | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Thoracic Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1164/rccm.202306-1025LE | - |
dc.relation.ispartof | American Journal of Respiratory and Critical Care Medicine, 2023, vol. 208, num.10, p. 1135-1137 | - |
dc.relation.uri | https://doi.org/10.1164/rccm.202306-1025LE | - |
dc.rights | (c) American Thoracic Society, 2023 | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Epigènesi | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Epigenesis | - |
dc.title | Genetic and Epigenetic Associations with Pre-COPD Lung Function Trajectories | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 740019 | - |
dc.date.updated | 2024-07-25T11:29:51Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37610423 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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833913.pdf | 415.89 kB | Adobe PDF | View/Open |
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