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http://hdl.handle.net/2445/214723
Title: | Genetic and Epigenetic Associations with Pre-COPD Lung Function Trajectories |
Author: | Martino, David J. Bui, Dinh S. Li, Shuai Idrose, Sabrina Perret, Jennifer Lowe, Adrian J. Lodge, Caroline J. Bowatte, Gayan Moodley, Yuben Thomas, Paul S. Zosky, Graeme Zosky, Graeme Holloway, John W. Svanes, Cecilie Faner, Rosa Walters, Eugene H. Dharmage, Shyamali C. |
Keywords: | Malalties pulmonars obstructives cròniques Epigènesi Chronic obstructive pulmonary diseases Epigenesis |
Issue Date: | 15-Nov-2023 |
Publisher: | American Thoracic Society |
Abstract: | <p>Understanding the molecular mechanisms of lung function trajectories that progress to chronic obstructive pulmonary disease (COPD) (pre-COPD trajectories), especially those with a rapidly declining phenotype, should inform preventive interventions. The Tasmanian Longitudinal Health Study (TAHS) previously defined life-course lung function trajectories by serial spirometry in a cohort of all seven-year-old school children in the state of Tasmania recruited in 1968 and followed up to age 53 years (1). Of the six pre-bronchodilator FEV1 lifetime trajectories identified, three collectively accounted for 75% of chronic obstructive pulmonary disease (COPD) prevalence at age 53 years (2). These high-risk trajectories were: 1) early below average lung function (with usual rate of subsequent decline), 2) persistently low, and 3) early below average lung function with accelerated decline. The TAHS cohort provides a unique opportunity to investigate molecular factors associated with disadvantaged trajectories, and we conducted a pilot study in this cohort to characterize associations with COPD high-risk trajectories to inform more extensive longitudinal studies in the future.</p> |
Note: | Versió postprint del document publicat a: https://doi.org/10.1164/rccm.202306-1025LE |
It is part of: | American Journal of Respiratory and Critical Care Medicine, 2023, vol. 208, num.10, p. 1135-1137 |
URI: | http://hdl.handle.net/2445/214723 |
Related resource: | https://doi.org/10.1164/rccm.202306-1025LE |
ISSN: | 1073-449X |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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