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https://hdl.handle.net/2445/215662| Title: | Photocontrol of endogenous glycine receptors in vivo |
| Author: | Gomila, Alexandre MJ Rustler, Karin Maleeva, Galyna Nin-Hill, Alba Wutz, Daniel Bautista-Barrufet, Antoni Rovira, Xavier Bosch, Miquel Mukhametova, Elvira Petukhova, Elena Ponomareva, Daria Mukhamedyarov, Marat Peiretti, Franck Alfonso Prieto, Mercedes Rovira i Virgili, Carme König, Burkhard Bregestovski, Piotr Gorostiza, Pau |
| Keywords: | Fotoquímica Fotofarmacologia Photochemistry Photopharmacology |
| Issue Date: | 19-Nov-2020 |
| Publisher: | Elsevier Inc. |
| Abstract: | Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.chembiol.2020.08.005 |
| It is part of: | Cell Chemical Biology, 2020, vol. 27, p. 1425-1433 |
| URI: | https://hdl.handle.net/2445/215662 |
| Related resource: | https://doi.org/10.1016/j.chembiol.2020.08.005 |
| ISSN: | 2451-9456 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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| 847649.pdf | 4.48 MB | Adobe PDF | View/Open |
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