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https://hdl.handle.net/2445/216990| Title: | New immunotherapeutic strategies in acute leukemia |
| Author: | Tirado Cabrera, Néstor |
| Director/Tutor: | Menéndez Buján, Pablo Sánchez Martínez, Diego |
| Keywords: | Immunologia Immunoteràpia Hematologia Leucèmia aguda Immunology Immunotheraphy Hematology Acute leukemia |
| Issue Date: | 20-Sep-2024 |
| Publisher: | Universitat de Barcelona |
| Abstract: | [eng] AIMS: The general aim of this doctoral thesis is to improve current CAR-T immunotherapeutic strategies in the treatment of acute leukemias. The specific aims of this doctoral thesis are: 1. To develop and characterize CD123-directed CAR-DOT cells as an allogeneic-safe, off-the-shelf therapy far the treatment of R/R AML. 2. To engineer CD1axCD3 BiTE-secreting STAb-T cells and compare their effectiveness against conventional CD1a-directed CAR-T cells against coT-ALL. 3. To generate a CCR9-directed immunotherapy far the safe treatment of R/R T-ALL. (i) To validate CCR9 as an immunotherapeutic target far T-ALL. (ii) To generate CCR9-directed CAR-T cells. (iii) To generate dual CCR9/CD1 a-directed CAR. |
| URI: | https://hdl.handle.net/2445/216990 |
| Appears in Collections: | Tesis Doctorals - Facultat - Medicina i Ciències de la Salut |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| NTC_PhD_THESIS.pdf | 89.77 MB | Adobe PDF | View/Open |
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