Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222399
Title: Diabetes-Related Dietary Patterns and Endometrial Cancer Risk and Survival in the European Prospective Investigation into Cancer and Nutrition Study
Author: Torres Laiton, Luisa
Luján Barroso, Leila
Nadal Zaragoza, Núria
Castro Espin, Carlota
Jakszyn, Paula
Panico, Camilla
Cornet, Charlotte Le
Dahm, Christina C.
Petrova, Dafina
Rodríguez Palacios, Daniel Ángel
Jannasch, Franziska
Masala, Giovanna
Dossus, Laure
Padroni, Lisa
Guevara, Marcela
Schulze, Matthias B.
Fortner, Renée T.
Tumino, Rosario
Crous Bou, Marta
Keywords: Complicacions de la diabetis
Càncer d'endometri
Diabetes complications
Endometrial cancer
Issue Date: 12-May-2025
Publisher: MDPI AG
Abstract: Background/Objectives: Endometrial cancer (EC)'s major risk factors include obesity and diabetes, both strongly related with lifestyle choices and dietary factors. Our study aimed to evaluate the relationship between diabetes-related dietary patterns, EC risk, and survival in a population of middle-aged European women. Methods: A total of 285,418 female participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included in the analysis. After a mean time of 10.6 years of follow-up, 1955 incident EC cases were registered; of those, 133 women died from EC. The Empirical Dietary Index for Insulin Resistance (EDIR), the Empirical Dietary Index for Hyperinsulinemia (EDIH), and the Diabetes Risk Reduction Diet (DRRD), were estimated from dietary information collected at baseline from EPIC participants. Cox proportional hazards regression models were used to evaluate the association between the dietary patterns and EC risk, using hazard ratios (HR), 95% confidence intervals (CI), and adjusting for relevant confounders. Cox and Fine-Gray models were used to assess the association with overall and EC-specific mortality, respectively. Results: Higher adherence to EDIR was associated with an increased risk of EC, multivariable HR for T3vsT1 were 1.17 (95% CI = 1.04 to1.31). However, when BMI was included in the models, these associations became weaker and no longer statistically significant. No associations were observed in relation to adherence to EDIH, DRRD, and EC risk. No associations were found in relation to diabetes-related dietary patterns and mortality. Conclusions: This study highlights the potential role of diabetes related dietary patterns and EC etiology and prevention. Further studies are warranted to better understand the role of etiology-derived dietary patterns and disease prevention and prognosis.
Note: Reproducció del document publicat a: https://doi.org/10.3390/nu17101645
It is part of: Nutrients, 2025, vol. 17, num. 10, p. 1645
URI: https://hdl.handle.net/2445/222399
Related resource: https://doi.org/10.3390/nu17101645
ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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