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https://hdl.handle.net/2445/222655| Title: | CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis |
| Author: | Sans de San Nicolàs, Lídia Czarnowicki, Tali Akdis, Mubeccel Pujol, Ramon M. Lozano-Ojalvo, Daniel Leung, Donald Y. M. Guttman-Yassky, Emma Santamaria Babí, Luis F. |
| Keywords: | Marcadors bioquímics Dermatitis atòpica Cèl·lules T Biochemical markers Atopic dermatitis T cells |
| Issue Date: | 13-Jul-2023 |
| Publisher: | John Wiley & Sons |
| Abstract: | Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1111/all.15816 |
| It is part of: | Allergy, 2024, vol. 79, num.1, p. 15-25 |
| URI: | https://hdl.handle.net/2445/222655 |
| Related resource: | https://doi.org/10.1111/all.15816 |
| ISSN: | 0105-4538 |
| Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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