Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/222851
Title: | Novel risk loci for COVID-19 hospitalization among admixed American populations |
Author: | Diz de Almeida, Silvia Pujol Onofre, Aurora SCOURGE Cohort Group |
Keywords: | Polimorfisme genètic COVID-19 Genetic polymorphisms COVID-19 |
Issue Date: | 14-Feb-2024 |
Publisher: | eLife Sciences Publications, Ltd |
Abstract: | The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research. |
Note: | Reproducció del document publicat a: https://doi.org/10.7554/eLife.93666 |
It is part of: | eLife, 2024, vol. 13 |
URI: | https://hdl.handle.net/2445/222851 |
Related resource: | https://doi.org/10.7554/eLife.93666 |
ISSN: | 2050-084X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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