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https://hdl.handle.net/2445/223041
Title: | Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status |
Author: | Stein, Dan J., 1962- Ntwatwa, Ziphozihle Lochner, Christine Roos, Annerine Sevenoaks, Tatum van Honk, Jack Batistuzzo, Marcelo C. Choi, Sunah Hoexter, Marcelo Q. Kim, Minah Kwon, Jun Soo Mataix-Cols, David Menchón Magriñá, José Manuel Miguel, Euripedes C. Nakamae, Takashi Soriano Mas, Carles Veltman, Dick J. Groenewold, Nynke A. Van den Heuvel, Odile A. Ipser, Jonathan |
Keywords: | Cos amigdaloide Neurosi obsessiva Hipocamp (Cervell) Amygdaloid body Obsessive-compulsive disorder Hippocampus (Brain) |
Issue Date: | 20-Jun-2025 |
Publisher: | Canadian Medical Association |
Abstract: | Background: Although it has been suggested that the hippocampus and amygdala (HA) are involved in the neurobiology of obsessive–compulsive disorder (OCD), volumetric findings have been inconsistent, and little work has been undertaken on the volumetry of the heterogeneous anatomic units of HA, with their specific functions and cytoarchitecture, in OCD. We sought to explore potential sources of heterogeneity in brain volumes by performing a separate analysis for people with and without psychotropic medication use, as well as the association of subfield volumes with OCD symptom severity. Methods: We segmented T1-weighted images from people with OCD and healthy controls in the OCD Brain Imaging Consortium to produce 12 hippocampal subfields and 9 amygdala subfields using Free-Surfer 6.0. We assessed between-group differences in subfield volume using a mixed-effects model adjusted for age and quadratic effects of age, sex, site, and whole HA volume. We also performed subgroup analyses to examine subfield volume in relation to comorbid anxiety and depression, medication status, and symptom severity. We corrected all analyses for multiple comparisons using the false discovery rate (FDR). Results: We included images from 381 people with OCD and 338 healthy controls. These groups did not significantly differ in HA subfield volumes. However, medicated people with OCD had significantly smaller volumes in the hippocampal dentate gyrus (pFDR = 0.04, d = −0.26) and molecular layer (pFDR = 0.04, d = −0.29), and larger volumes in the lateral (pFDR = 0.049, d = 0.23) and basal (pFDR = 0.049, d = 0.25) amygdala subfields, than healthy controls. Unmedicated people with OCD had significantly smaller volumes in the hippocampal cornu ammonis sector 1 (pFDR = 0.02, d = −0.28) than controls. We did not detect associations between any subfield volume and OCD severity. Limitations: We used cross-sectional data, which limits the interpretation of our analysis. Conclusion: Differences in HA subfields between people with OCD and healthy controls are dependent on medication status, in line with previous work on other brain volumetric alterations in OCD. This emphasizes the importance of considering psychotropic medication in neuroimaging studies of OCD. |
Note: | Reproducció del document publicat a: https://doi.org/10.1503/jpn.230119 |
It is part of: | Journal of Psychiatry & Neuroscience, 2025, vol. 50, num.3, p. E170-E180 |
URI: | https://hdl.handle.net/2445/223041 |
Related resource: | https://doi.org/10.1503/jpn.230119 |
ISSN: | 1180-4882 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) |
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