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dc.contributor.authorAlcántara Horrillo, Soledadcat
dc.contributor.authorFrisén, Jonáscat
dc.contributor.authorRío Fernández, José Antonio delcat
dc.contributor.authorSoriano García, Eduardocat
dc.contributor.authorBarbacid, Marianocat
dc.contributor.authorSilos-Santiago, Inmaculadacat
dc.description.abstractNewborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant increase in apoptotic cell death in different regions of the brain during early postnatal life. The most affected region in the brain is the dentate gyrus of the hippocampus, although elevated levels of pyknotic nuclei were also detected in cortical layers II and III and V and VI, the striatum, and the thalamus. Furthermore, axotomized hippocampal and motor neurons of trkB (¿/¿) mice have significantly lower survival rates than those of wild-type littermates. These results suggest that neurotrophin signaling through TrkB receptors plays a role in the survival of CNS neurons during postnatal development. Moreover, they indicate that TrkB receptor signaling protects subpopulations of CNS neurons from injury- and axotomy-induced cell death.eng
dc.format.extent11 p.-
dc.publisherSociety for Neuroscience-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofThe Journal of Neuroscience, 1997, vol. 17, num. 10, p. 3623-3633-
dc.rights(c) Society for Neuroscience, 1997-
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)-
dc.subject.classificationHipocamp (Cervell)cat
dc.subject.classificationNeurones motorescat
dc.subject.classificationTransducció de senyal cel·lularcat
dc.subject.otherHippocampus (Brain)eng
dc.subject.otherMotor neuronseng
dc.subject.otherCellular signal transductioneng
dc.titleTrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell deatheng
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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