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Title: TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death
Author: Alcántara Horrillo, Soledad
Frisén, Jonás
Río Fernández, José Antonio del
Soriano García, Eduardo
Barbacid, Mariano
Silos-Santiago, Inmaculada
Keywords: Hipocamp (Cervell)
Neurones motores
Transducció de senyal cel·lular
Hippocampus (Brain)
Motor neurons
Cellular signal transduction
Issue Date: 1997
Publisher: Society for Neuroscience
Abstract: Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant increase in apoptotic cell death in different regions of the brain during early postnatal life. The most affected region in the brain is the dentate gyrus of the hippocampus, although elevated levels of pyknotic nuclei were also detected in cortical layers II and III and V and VI, the striatum, and the thalamus. Furthermore, axotomized hippocampal and motor neurons of trkB (¿/¿) mice have significantly lower survival rates than those of wild-type littermates. These results suggest that neurotrophin signaling through TrkB receptors plays a role in the survival of CNS neurons during postnatal development. Moreover, they indicate that TrkB receptor signaling protects subpopulations of CNS neurons from injury- and axotomy-induced cell death.
Note: Reproducció del document publicat a:
It is part of: The Journal of Neuroscience, 1997, vol. 17, num. 10, p. 3623-3633
ISSN: 0270-6474
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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