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DC Field | Value | Language |
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dc.contributor.author | Carbonell Sanroma, Albert | - |
dc.contributor.author | Mazo, A. | - |
dc.contributor.author | Serras Rigalt, Florenci | - |
dc.contributor.author | Corominas, Montserrat (Corominas Guiu) | - |
dc.date.accessioned | 2013-03-13T15:54:36Z | - |
dc.date.available | 2013-04-01T22:01:05Z | - |
dc.date.issued | 2013-02-01 | - |
dc.identifier.issn | 1059-1524 | - |
dc.identifier.uri | http://hdl.handle.net/2445/34233 | - |
dc.description.abstract | The molting hormone ecdysone triggers chromatin changes via histone modifica- tions that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-related protein (Trr). Methylation of histone H3 at lysine 4 (H3K4me), which is associated with tran- scriptional activation, requires several cofactors, including Ash2. We find that ash2 mutants have severe defects in pupariation and metamorphosis due to a lack of activation of ecdy- sone-responsive genes. This transcriptional defect is caused by the absence of the H3K4me3 marks set by Trr in these genes. We present evidence that Ash2 interacts with Trr and is re- quired for its stabilization. Thus we propose that Ash2 functions together with Trr as an ecdysone receptor coactivator. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Cell Biology | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1091/mbc.E12-04-0267 | - |
dc.relation.ispartof | Molecular Biology of the Cell, 2013, vol. 24, num. 3, p. 361-372 | - |
dc.relation.uri | http://dx.doi.org/10.1091/mbc.E12-04-0267 | - |
dc.rights | cc-by-nc-sa (c) Carbonell Sanroma, Albert et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.classification | Regulació genètica | - |
dc.subject.classification | Mutació (Biologia) | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Genetic regulation | - |
dc.subject.other | Mutation (Biology) | - |
dc.title | Ash2 acts as an Ecdysone Receptor coactivator by stabilizing the histone methyltransferase Trr. | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 620812 | - |
dc.date.updated | 2013-03-13T14:18:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23197473 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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File | Description | Size | Format | |
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620812.pdf | 4.8 MB | Adobe PDF | View/Open |
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