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http://hdl.handle.net/2445/34526| Title: | Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model |
| Author: | Kurdián, Melania Herrero Fresneda, Immaculada Lloberas Blanch, Núria Giménez Bonafé, Pepita Coria, Virginia Grande, María T. Boggia, José Malacrida, Leonel Torras Ambròs, Joan Arévalo, Miguel A. González-Martínez, Francisco López-Novoa, José M. Grinyó Boira, Josep M. Noboa, Oscar |
| Keywords: | Medicaments Transplantament renal Proteïnúria Immunosupressió Drugs Kidney transplantation Proteinuria Immunosuppression |
| Issue Date: | 12-Mar-2012 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats. |
| Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0032516 |
| It is part of: | PLoS One, 2012, vol. 7, núm. 3, p. e32516 |
| URI: | http://hdl.handle.net/2445/34526 |
| Related resource: | http://dx.doi.org/10.1371/journal.pone.0032516 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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