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DC Field | Value | Language |
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dc.contributor.author | Morales, Eva | - |
dc.contributor.author | Bustamante Pineda, Mariona | - |
dc.contributor.author | González, Juan R. | - |
dc.contributor.author | Guxens, Mònica | - |
dc.contributor.author | Torrent, Maties | - |
dc.contributor.author | Méndez, Michelle | - |
dc.contributor.author | García-Esteban, Raquel | - |
dc.contributor.author | Julvez, Jordi | - |
dc.contributor.author | Forns, Joan | - |
dc.contributor.author | Vrijheid, Martine | - |
dc.contributor.author | Moltó-Puigmartí, Carolina | - |
dc.contributor.author | López Sabater, María del Carmen | - |
dc.contributor.author | Estivill, Xavier, 1955- | - |
dc.contributor.author | Sunyer Deu, Jordi | - |
dc.date.accessioned | 2013-04-11T15:30:58Z | - |
dc.date.available | 2013-04-11T15:30:58Z | - |
dc.date.issued | 2011-02-23 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/34531 | - |
dc.description.abstract | Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children"s Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0017181 | - |
dc.relation.ispartof | PLoS One, 2011, vol. 6, num. 2, p. e17181 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0017181 | - |
dc.rights | cc-by (c) Morales, Eva et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Àcids grassos | - |
dc.subject.classification | Enzims | - |
dc.subject.classification | Llet materna | - |
dc.subject.classification | Genètica humana | - |
dc.subject.classification | Cognició en els infants | - |
dc.subject.other | Fatty acids | - |
dc.subject.other | Enzymes | - |
dc.subject.other | Breast milk | - |
dc.subject.other | Human genetics | - |
dc.subject.other | Cognition in children | - |
dc.title | Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 589716 | - |
dc.date.updated | 2013-04-11T15:30:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21383846 | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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