Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/43202
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rodríguez-Frías, Francisco | - |
dc.contributor.author | Tabernero, David | - |
dc.contributor.author | Quer, Josep | - |
dc.contributor.author | Esteban, Juan I. | - |
dc.contributor.author | Ortega, Israel | - |
dc.contributor.author | Domingo, Esteban | - |
dc.contributor.author | Cubero, Maria | - |
dc.contributor.author | Camos, Sílvia | - |
dc.contributor.author | Ferrer Costa, Carles | - |
dc.contributor.author | Sànchez, Àlex (Sànchez Pla) | - |
dc.contributor.author | Jardí, Rosendo | - |
dc.contributor.author | Schaper, Melanie | - |
dc.contributor.author | Homs, Maria | - |
dc.contributor.author | García Cehic, Damir | - |
dc.contributor.author | Guardia, Jaume | - |
dc.contributor.author | Esteban, Rafael | - |
dc.contributor.author | Buti, Maria | - |
dc.date.accessioned | 2013-05-07T17:43:09Z | - |
dc.date.available | 2013-05-07T17:43:09Z | - |
dc.date.issued | 2012-05-30 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43202 | - |
dc.description.abstract | Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0037874 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 5, p. e37874 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0037874 | - |
dc.rights | cc-by (c) Rodriguez Frías, F. et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Hepatitis B | - |
dc.subject.classification | Medicaments antivírics | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Hepatitis B | - |
dc.subject.other | Antiviral agents | - |
dc.subject.other | Gene expression | - |
dc.title | Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 614276 | - |
dc.date.updated | 2013-05-07T17:43:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22666402 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
614276.pdf | 703.15 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License