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Title: | Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics |
Author: | García Garcerà, M. Gigli, E. Sánchez Quinto, Federico Ramírez, Oscar Calafell, Francesc Civit Vives, Sergi Lalueza Fox, Carles, 1965- |
Keywords: | ADN fòssil ADN Paleobiologia Fossil DNA DNA Paleobiology |
Issue Date: | 2011 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Despite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmentation of ancient DNA sequences is a characteristic trait primarily arising due to depurination processes that create abasic sites leading to DNA breaks. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0024161 |
It is part of: | PLoS One, 2011, vol. 6, num. 8, p. e24161 |
URI: | http://hdl.handle.net/2445/43561 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0024161 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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