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Title: Dietary resveratrol prevents alzheimer's markers and increases life span in SAMP8
Author: Porquet Costa, David
Casadesús, Gemma
Bayod Gimeno, Sergi
Vicente, Alberto
Canudas Teixidó, Anna-Maria
Vilaplana i Hortensi, Jordi
Pelegrí i Gabaldà, Carme
Sanfeliu i Pujol, Coral
Camins Espuny, Antoni
Pallàs i Llibería, Mercè, 1964-
Valle i Macià, Jaume del
Keywords: Envelliment
Malalties neurodegeneratives
Malaltia d'Alzheimer
Ratolins (Animals de laboratori)
Neurodegenerative Diseases
Alzheimer's disease
Mice (Laboratory animals)
Issue Date: 1-Oct-2013
Publisher: Springer Verlag
Abstract: Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation. Resveratrol increases metabolic rate, insulin sensitivity, mitochondrial biogenesis and physical endurance, and reduces fat accumulation in mice. In addition, resveratrol may be a powerful agent to prevent age-associated neurodegeneration and to improve cognitive deficits in Alzheimer's disease (AD). Moreover, different findings support the view that longevity in mice could be promoted by CR. In this study, we examined the role of dietary resveratrol in SAMP8 mice, a model of age-related AD. We found that resveratrol supplements increased mean life expectancy and maximal life span in SAMP8 and in their control, the related strain SAMR1. In addition, we examined the resveratrol-mediated neuroprotective effects on several specific hallmarks of AD. We found that long-term dietary resveratrol activates AMPK pathways and pro-survival routes such as SIRT1 in vivo. It also reduces cognitive impairment and has a neuroprotective role, decreasing the amyloid burden and reducing tau hyperphosphorylation.
Note: Versió postprint del document publicat a:
It is part of: AGE, 2013, vol. 35, num. 5, p. 1851-1865
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ISSN: 0161-9152
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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