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http://hdl.handle.net/2445/53332| Title: | The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression |
| Author: | Saurí Duran, Jaume Millán, D. Suñé i Negre, Josep M. (Josep Maria) Pérez Lozano, Pilar Sarrate Arjona, Rocio Fábregas, A. (Anna) Carrillo Sánchez, Carolina Miñarro Carmona, Montserrat Ticó Grau, Josep R. García Montoya, Encarna |
| Keywords: | Comprimits (Medicina) Medicació oral Excipients Control de qualitat Medicaments d'alliberament retardat Tecnologia farmacèutica Pólvores (Farmàcia) Tablets (Medicine) Oral medication Excipients Quality control Delayed-action drugs Pharmaceutical technology Powders (Pharmacy) |
| Issue Date: | 30-Jan-2014 |
| Publisher: | Elsevier B.V. |
| Abstract: | The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses. |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.ijpharm.2013.11.029 |
| It is part of: | International Journal of Pharmaceutics, 2014, vol. 461, num. 1-2, p. 38-45 |
| URI: | http://hdl.handle.net/2445/53332 |
| Related resource: | http://dx.doi.org/10.1016/j.ijpharm.2013.11.029 |
| ISSN: | 0378-5173 |
| Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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|---|---|---|---|---|
| 630651.pdf | 1.69 MB | Adobe PDF | View/Open |
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