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Title: The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
Author: Saurí Duran, Jaume
Millán, D.
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
Sarrate Arjona, Rocio
Fábregas, A. (Anna)
Carrillo Sánchez, Carolina
Miñarro Carmona, Montserrat
Ticó Grau, Josep R.
García Montoya, Encarna
Keywords: Comprimits (Medicina)
Medicació oral
Control de qualitat
Medicaments d'alliberament retardat
Tecnologia farmacèutica
Pólvores (Farmàcia)
Tablets (Medicine)
Oral medication
Quality control
Delayed-action drugs
Pharmaceutical technology
Powders (Pharmacy)
Issue Date: 30-Jan-2014
Publisher: Elsevier B.V.
Abstract: The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.
Note: Versió postprint del document publicat a:
It is part of: International Journal of Pharmaceutics, 2014, vol. 461, num. 1-2, p. 38-45
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ISSN: 0378-5173
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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