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DC Field | Value | Language |
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dc.contributor.author | Miravitlles Fernández, Marc | - |
dc.contributor.author | Huerta, Alicia | - |
dc.contributor.author | Fernández-Villar, José Alberto | - |
dc.contributor.author | Alcázar, Bernardino | - |
dc.contributor.author | Villa, Guillermo | - |
dc.contributor.author | Forné, Carles | - |
dc.contributor.author | Cuesta, Maribel | - |
dc.contributor.author | Crespo, Carlos | - |
dc.contributor.author | García Río, Francisco | - |
dc.date.accessioned | 2014-10-13T13:41:09Z | - |
dc.date.available | 2014-10-13T13:41:09Z | - |
dc.date.issued | 2014-09-05 | - |
dc.identifier.issn | 1477-7525 | - |
dc.identifier.uri | http://hdl.handle.net/2445/58544 | - |
dc.description.abstract | Background To determine generic utilities for Spanish chronic obstructive pulmonary disease (COPD) patients stratified by different classifications: GOLD 2007, GOLD 2013, GesEPOC 2012 and BODEx index. Methods Multicentre, observational, cross-sectional study. Patients were aged ≥40 years, with spirometrically confirmed COPD. Utility values were derived from EQ-5D-3 L. Means, standard deviations (SD), medians and interquartile ranges (IQR) were computed based on the different classifications. Differences in median utilities between groups were assessed by non-parametric tests. Results 346 patients were included, of which 85.5% were male with a mean age of 67.9 (SD = 9.7) years and a mean duration of COPD of 7.6 (SD = 5.8) years; 80.3% were ex-smokers and the mean smoking history was 54.2 (SD = 33.2) pack-years. Median utilities (IQR) by GOLD 2007 were 0.87 (0.22) for moderate; 0.80 (0.26) for severe and 0.67 (0.42) for very-severe patients (p < 0.001 for all comparisons). Median utilities by GOLD 2013 were group A: 1.0 (0.09); group B: 0.87 (0.13); group C: 1.0 (0.16); group D: 0.74 (0.29); comparisons were statistically significant (p < 0.001) except A vs C. Median utilities by GesEPOC phenotypes were 0.84 (0.33) for non exacerbator; 0.80 (0.26) for COPD-asthma overlap; 0.71 (0.62) for exacerbator with emphysema; 0.72 (0.57) for exacerbator with chronic bronchitis (p < 0.001). Comparisons between patients with or without exacerbations and between patients with COPD-asthma overlap and exacerbator with chronic bronchitis were statistically-significant (p < 0.001). Median utilities by BODEx index were: group 0<br>2: 0.89 (0.20); group 3<br>4: 0.80 (0.27); group 5<br>6: 0.67 (0.29); group 7<br>9: 0.41 (0.31). All comparisons were significant (p < 0.001) except between groups 3<br>4 and 5<br>6. Conclusion Irrespective of the classification used utilities were associated to disease severity. Some clinical phenotypes were associated with worse utilities, probably related to a higher frequency of exacerbations. GOLD 2007 guidelines and BODEx index better discriminated patients with a worse health status than GOLD 2013 guidelines, while GOLD 2013 guidelines were better able to identify a smaller group of patients with the best health. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/s12955-014-0120-5 | - |
dc.relation.ispartof | Health And Quality Of Life Outcomes, 2014, vol. 12, num. 9, p. 120 | - |
dc.relation.uri | http://dx.doi.org/10.1186/s12955-014-0120-5 | - |
dc.rights | cc-by (c) Miravitlles Fernández, Marc et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Espanya | - |
dc.subject.classification | Economia de la salut | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Spain | - |
dc.subject.other | Medical economics | - |
dc.title | Generic utilities in chronic obstructive pulmonary disease patients stratified according to different staging systems. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 643066 | - |
dc.date.updated | 2014-10-13T13:41:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25189786 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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