Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/58563
Title: | Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts |
Author: | Corella Piquer, Dolores González, José Ignacio Bulló, Mònica Carrasco, Paula Portolés, Olga Díez Espino, Javier Covas Planells, María Isabel Ruiz-Gutiérrez, Valentina Gómez Gracia, Enrique Arós, Fernando Fiol Sala, Miguel Conde Herrera, Manuel Santos, José Manuel Sáez Tormo, Guillermo Lamuela Raventós, Rosa Ma. Lahoz, Carlos Vinyoles, Ernest Ros Rahola, Emilio Estruch Riba, Ramon |
Keywords: | Malalties cardiovasculars Inflamació Cuina mediterrània Suplements nutritius Olis vegetals Oli d'oliva Fruita seca Polimorfisme genètic Marcadors bioquímics Interleucines Cardiovascular diseases Inflammation Mediterranean cooking Dietary supplements Vegetable oils Olive oil Dried fruit Genetic polymorphisms Biochemical markers Interleukins |
Issue Date: | 3-Dec-2008 |
Publisher: | American Society for Nutrition |
Abstract: | Inflammation is involved in cardiovascular diseases. Some studies have found that the Mediterranean diet (MD) can reduce serum concentrations of inflammation markers. However, none of these studies have analyzed the influence of genetic variability in such a response. Our objective was to study the effect of the -765G.C polymorphism in the cyclooxygenase-2 (COX-2) gene and the -174G.C polymorphism in the interleukin-6 (IL-6) gene on serum concentrations of IL-6, C-reactive protein, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 as well as their influence on the response toa nutritional interventionwithMD.An intervention study ina high cardiovascular riskMediterranean population (314 men and 407 women) was undertaken. Participants were randomly assigned to consume a low-fat control diet or a MD supplementedwith virgin olive oil ornuts.Measureswereobtained at baseline and after a 3-mointervention period.At baseline, the COX-2 -765G.C polymorphismwas associated with lower serum IL-6 (5.85 6 4.82 in GG vs. 4.74 6 4.14 ng/L in C-allele carriers; P ¼ 0.002) and ICAM-1 (265.8 6 114.8 in GG vs. 243.0 6 107.1 mg/L in C-carriers; P ¼ 0.018) concentrations. These differences remained significant aftermultivariate adjustment. The IL-6 -174G.C polymorphism was associatedwith higher (CC vs. G-carriers) serumICAM-1concentrations in bothmenandwomenandwithhigherserumIL-6 concentrations inmen.Following the dietary intervention, no significant gene x diet interactions were found. In conclusion, although COX-2 -765G.C and IL-6 -174G.C polymorphismswere associatedwith inflammation, consuming aMD(either supplemented with virgin olive oil or nuts) reduced the concentration of inflammation markers regardless of these polymorphisms. |
Note: | http://dx.doi.org/10.3945/jn.108.093054 |
It is part of: | Journal of Nutrition, 2008, vol. 139, num. 1, p. 128-134 |
URI: | http://hdl.handle.net/2445/58563 |
Related resource: | http://dx.doi.org/10.3945/jn.108.093054 |
ISSN: | 0022-3166 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
621818.pdf | 689.51 kB | Adobe PDF | View/Open Request a copy |
Document embargat fins el 1-1-2099
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.