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http://hdl.handle.net/2445/64765| Title: | Potential of caveolae in the therapy of cardiovascular and neurological diseases. |
| Author: | Navarro Brugal, Gemma Borroto Escuela, Dasiel Oscar Fuxe, Kjell Franco Fernández, Rafael |
| Keywords: | Malalties del sistema nerviós Membranes cel·lulars Malalties cardiovasculars Proteïnes de membrana Nervous system Diseases Cell membranes Cardiovascular diseases Membrane proteins |
| Issue Date: | 30-Sep-2014 |
| Publisher: | Frontiers Media |
| Abstract: | Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases. |
| Note: | Reproducció del document publicat a: http://dx.doi.org/10.3389/fphys.2014.00370 |
| It is part of: | Frontiers in Physiology , 2014, vol. 5, p. 1-8 |
| URI: | http://hdl.handle.net/2445/64765 |
| Related resource: | http://dx.doi.org/10.3389/fphys.2014.00370 |
| ISSN: | 1664-042X |
| Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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