Please use this identifier to cite or link to this item:
Title: Evolutionary dynamics of molecular markers during local adaptation: a case study in Drosophila subobscura
Author: Simões, Pedro
Pascual Berniola, Marta
Santos, Josiane
Rose, Michael R.
Matos, Margarida
Keywords: Drosòfila subobscura
Variació (Biologia)
Genètica evolutiva
Drosophila subobscura
Variation (Biology)
Evolutionary genetics
Issue Date: 2008
Publisher: BioMed Central
Abstract: Background: Natural selection and genetic drift are major forces responsible for temporal genetic changes in populations. Furthermore, these evolutionary forces may interact with each other. Here we study the impact of an ongoing adaptive process at the molecular genetic level by analyzing the temporal genetic changes throughout 40 generations of adaptation to a common laboratory environment. Specifically, genetic variability, population differentiation and demographic structure were compared in two replicated groups of Drosophila subobscura populations recently sampled from different wild sources. Results: We found evidence for a decline in genetic variability through time, along with an increase in genetic differentiation between all populations studied. The observed decline in genetic variability was higher during the first 14 generations of laboratory adaptation. The two groups of replicated populations showed overall similarity in variability patterns. Our results also revealed changing demographic structure of the populations during laboratory evolution, with lower effective population sizes in the early phase of the adaptive process. One of the ten microsatellites analyzed showed a clearly distinct temporal pattern of allele frequency change, suggesting the occurrence of positive selection affecting the region around that particular locus. Conclusion: Genetic drift was responsible for most of the divergence and loss of variability between and within replicates, with most changes occurring during the first generations of laboratory adaptation. We also found evidence suggesting a selective sweep, despite the low number of molecular markers analyzed. Overall, there was a similarity of evolutionary dynamics at the molecular level in our laboratory populations, despite distinct genetic backgrounds and some differences in phenotypic evolution.
Note: Reproducció del document publicat a
It is part of: Bmc Evolutionary Biology, 2008, vol. 8, núm. 66
Related resource:
ISSN: 1471-2148
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Files in This Item:
File Description SizeFormat 
562567.pdf321.55 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons