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http://hdl.handle.net/2445/95987
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DC Field | Value | Language |
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dc.contributor.author | Rabassa Bonet, Montserrat | - |
dc.contributor.author | Cherubini, Antonio | - |
dc.contributor.author | Zamora-Ros, Raul | - |
dc.contributor.author | Urpí Sardà, Mireia | - |
dc.contributor.author | Bandinelli, Stefania | - |
dc.contributor.author | Ferrucci, Luigi | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.date.accessioned | 2016-02-29T17:09:37Z | - |
dc.date.available | 2016-05-31T22:01:24Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0002-8614 | - |
dc.identifier.uri | http://hdl.handle.net/2445/95987 | - |
dc.description.abstract | Objectives: To investigate the association of total urinary polyphenols (TUP) and total dietary polyphenols (TDP) with cognitive decline in an older population. Design: The Invecchiare in Chianti (InCHIANTI) study, a cohort study with a 3-year of follow-up. Setting: tuscany, italy. Participants: Non-demented adults aged 65 and older (N=652). Measurements: TUP and TDP concentrations were analysed at baseline using the Folin-Ciocalteu assay and a validated food frequency questionnaire, respectively. Cognition was assessed using the Mini-Mental State Examination (MMSE) and Trail Making Test (TMT) at baseline and after three years of follow-up. A substantial cognitive decline was defined as a reduction in the MMSE score of 3 or more points and as an increase of at least 29 seconds on the TMT A and 68 seconds on the TMT B (these thresholds represent the worst 10% of the distribution of decline) or as test discontinued due to multiple mistakes in TMT A and B at follow-up. Results: Higher TUP levels were associated with lower risk of substantial cognitive decline on the MMSE (odds ratio [OR] comparing extreme tertiles = 0.53; 95% confidence interval [CI] = 0.34<br>0.85; P-trend = 0.008) and on the TMT-A (OR = 0.52; 95 % CI = 0.28<br>0.96; P-trend = 0.03), but not on TMT-B in a logistic regression model that adjusted for baseline cognitive score and potential confounding factors. TDP did not affect the developing substantial cognitive decline in both tests. Conclusion: High concentrations of polyphenols, a nutritional biomarker of polyphenol intake, were associated with a lower risk of substantial cognitive decline in the older population studied over a three-year period, suggesting a protective effect against cognitive impairment. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1111/jgs.13379 | - |
dc.relation.ispartof | Journal of the American Geriatrics Society, 2015, vol. 63, num. 5, p. 938-946 | - |
dc.relation.uri | http://dx.doi.org/10.1111/jgs.13379 | - |
dc.rights | (c) The American Geriatrics Society, 2015 | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Trastorns de la cognició | - |
dc.subject.classification | Polifenols | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.other | Cognition disorders | - |
dc.subject.other | Polyphenols | - |
dc.subject.other | Biochemical markers | - |
dc.title | Low levels of a urinary biomarker of dietary polyphenol are associated with substantial cognition decline over a three-year period in older adults: the Invecchiare in Chianti (InCHIANTI) Study. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 647358 | - |
dc.date.updated | 2016-02-29T17:09:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25919574 | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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File | Description | Size | Format | |
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647358.pdf | 448.04 kB | Adobe PDF | View/Open |
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