Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/96212
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alaña, Lide | - |
dc.contributor.author | Sesé i Faustino, Marta | - |
dc.contributor.author | Cánovas, Verónica | - |
dc.contributor.author | Punyal, Yolanda | - |
dc.contributor.author | Fernández, Yolanda | - |
dc.contributor.author | Abasolo, Ibane | - |
dc.contributor.author | Torres, Inés de | - |
dc.contributor.author | Ruiz, Cristina | - |
dc.contributor.author | Espinosa Blay, Lluís | - |
dc.contributor.author | Bigas Salvans, Anna | - |
dc.contributor.author | Ramón y Cajal Agüeras, Santiago | - |
dc.contributor.author | Fernández Ruiz, Pedro Luis | - |
dc.contributor.author | Serras Rigalt, Florenci | - |
dc.contributor.author | Corominas, Montserrat (Corominas Guiu) | - |
dc.contributor.author | Thomson, Timothy M. | - |
dc.contributor.author | Paciucci Barzanti, Rosanna | - |
dc.date.accessioned | 2016-03-07T16:12:57Z | - |
dc.date.available | 2016-03-07T16:12:57Z | - |
dc.date.issued | 2014-03-31 | - |
dc.identifier.issn | 1476-4598 | - |
dc.identifier.uri | http://hdl.handle.net/2445/96212 | - |
dc.description.abstract | Background PTOV1 is an adaptor protein with functions in diverse processes, including gene transcription and protein translation, whose overexpression is associated with a higher proliferation index and tumor grade in prostate cancer (PC) and other neoplasms. Here we report its interaction with the Notch pathway and its involvement in PC progression. Methods Stable PTOV1 knockdown or overexpression were performed by lentiviral transduction. Protein interactions were analyzed by co-immunoprecipitation, pull-down and/or immunofluorescence. Endogenous gene expression was analyzed by real time RT-PCR and/or Western blotting. Exogenous promoter activities were studied by luciferase assays. Gene promoter interactions were analyzed by chromatin immunoprecipitation assays (ChIP). In vivo studies were performed in the Drosophila melanogaster wing, the SCID-Beige mouse model, and human prostate cancer tissues and metastasis. The Excel package was used for statistical analysis [...]. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/1476-4598-13-74 | - |
dc.relation.ispartof | Molecular Cancer, 2014, vol. 13, num. 74, p. 1-16 | - |
dc.relation.uri | http://dx.doi.org/10.1186/1476-4598-13-74 | - |
dc.rights | cc-by (c) Alaña, Lide et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Càncer de pròstata | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.other | Prostate cancer | - |
dc.subject.other | Tumor markers | - |
dc.title | Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 641814 | - |
dc.date.updated | 2016-03-07T16:13:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24684754 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
641814.pdf | 3.38 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License