Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/97645
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Escudero, Beatriz | - |
dc.contributor.author | Lucas, Daniel | - |
dc.contributor.author | Albo, Carmen | - |
dc.contributor.author | Dhup, Suveera | - |
dc.contributor.author | Bacher, Jeff W. | - |
dc.contributor.author | Sánchez, Aránzazu | - |
dc.contributor.author | Fernández, Margarita | - |
dc.contributor.author | Rivera Torres, José | - |
dc.contributor.author | Carmona, Rosa M. | - |
dc.contributor.author | Fuster, Encarnación | - |
dc.contributor.author | Carreiro, Candelas | - |
dc.contributor.author | Bernad, Raquel | - |
dc.contributor.author | González, Manuel A. | - |
dc.contributor.author | Andrés, Vicente | - |
dc.contributor.author | Blanco, Luis | - |
dc.contributor.author | Roche, Enrique | - |
dc.contributor.author | Fabregat Romero, Isabel | - |
dc.contributor.author | Samper, Enrique | - |
dc.contributor.author | Bernad, Antonio | - |
dc.date.accessioned | 2016-04-19T14:36:21Z | - |
dc.date.available | 2016-04-19T14:36:21Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/97645 | - |
dc.description.abstract | Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ−/−) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ−/− mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Polμ−/− deficiency on liver aging. We found that old Polμ−/− mice (>20 month) have greater liver regenerative capacity compared with wt animals. Old Polμ−/− liver showed reduced genomic instability and increased apoptosis resistance. However, Polμ−/− mice did not show an extended life span and other organs (e.g., heart) aged normally. Our results suggest that Polμ deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0093074 | - |
dc.relation.ispartof | PLoS One, 2014, vol. 9, num. 4, p. e93074 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0093074 | - |
dc.rights | cc-by (c) Escudero, Beatriz et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Apoptosi | - |
dc.subject.classification | Reparació de l'ADN | - |
dc.subject.classification | Estrès oxidatiu | - |
dc.subject.classification | Envelliment | - |
dc.subject.other | Apoptosis | - |
dc.subject.other | DNA repair | - |
dc.subject.other | Oxidative stress | - |
dc.subject.other | Aging | - |
dc.title | Polμ deficiency increases resistance to oxidative damage and delays liver aging | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 648203 | - |
dc.date.updated | 2016-04-19T14:36:26Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/242038/EU//CARE-MI | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24691161 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
648203.pdf | 1.53 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License