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Title: | Polμ deficiency increases resistance to oxidative damage and delays liver aging |
Author: | Escudero, Beatriz Lucas, Daniel Albo, Carmen Dhup, Suveera Bacher, Jeff W. Sánchez, Aránzazu Fernández, Margarita Rivera Torres, José Carmona, Rosa M. Fuster, Encarnación Carreiro, Candelas Bernad, Raquel González, Manuel A. Andrés, Vicente Blanco, Luis Roche, Enrique Fabregat Romero, Isabel Samper, Enrique Bernad, Antonio |
Keywords: | Apoptosi Reparació de l'ADN Estrès oxidatiu Envelliment Apoptosis DNA repair Oxidative stress Aging |
Issue Date: | Apr-2014 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ−/−) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ−/− mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Polμ−/− deficiency on liver aging. We found that old Polμ−/− mice (>20 month) have greater liver regenerative capacity compared with wt animals. Old Polμ−/− liver showed reduced genomic instability and increased apoptosis resistance. However, Polμ−/− mice did not show an extended life span and other organs (e.g., heart) aged normally. Our results suggest that Polμ deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0093074 |
It is part of: | PLoS One, 2014, vol. 9, num. 4, p. e93074 |
URI: | http://hdl.handle.net/2445/97645 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0093074 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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