Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/99399
Title: | Total Synthesis of (+)-Madangamine D |
Author: | Ballette, Roberto Pérez Bosch, Maria Proto, Stefano Amat Tusón, Mercedes Bosch Cartes, Joan |
Keywords: | Farmacologia Esponges Alcaloides Productes naturals marins Pharmacology Sponges Alkaloids Marine natural products |
Issue Date: | 2-May-2014 |
Publisher: | Wiley-VCH |
Abstract: | Madangamines are a group of bioactive marine sponge alkaloids, embodying an unprecedented diazapentacyclic skeletal type. The enantioselective total synthesis of madangamine D has been accomplished, and represents the first total synthesis of an alkaloid of the madangamine group. It involves the stereoselective construction of the diazatricyclic ABC core using a phenylglycinol-derived lactam as the starting enantiomeric scaffold and the subsequent assembly of the peripheral macrocyclic rings. The synthesis provides, for the first time, a pure sample of madangamine D and confirms the absolute configuration of this alkaloid family. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1002/anie.201402263 |
It is part of: | Angewandte Chemie-International Edition, 2014, vol. 53, num. 24, p. 6202-6205 |
URI: | http://hdl.handle.net/2445/99399 |
Related resource: | http://dx.doi.org/10.1002/anie.201402263 |
ISSN: | 1433-7851 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
642020.pdf | 699.08 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.