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Title: | High prevalence of Pneumocystis jirovecii pneumonia among Mozambican children < 5 years of age admitted to hospital with clinical severe pneumonia |
Author: | Lanaspa, Miguel O'Callaghan Gordo, Cristina Machevo, Sonia Madrid, Lola Nhampossa, Tacilta Acácio, Sozinho Horra, C. de la Friaza, Vicente Campano, E. Alonso, Pedro Calderon, Enrique J. Roca, A. Bassat Orellana, Quique |
Keywords: | Pneumònia Infants Pneumonia Children |
Issue Date: | 28-Jul-2015 |
Publisher: | Elsevier |
Abstract: | We aimed to describe Pneumocystis jirovecii pneumonia (PCP) prevalence and features in children from sub-Saharan Africa, and to investigate PCP-associated risk factors. During 2006-2007 we used molecular methods to test children younger than 5 years old admitted with severe pneumonia to a hospital in Southern Mozambique for Pneumocystis infection. We recruited 834 children. PCP prevalence was 6.8% and HIV prevalence was 25.7%. The in-hospital and delayed mortality were significantly higher among children with PCP (20.8% vs. 10.2 %, p=0.021, and 11.5% vs. 3.6%, p=0.044, respectively). Clinical features were mostly overlapping between the two groups. Independent risk factors for PCP were age less than a year (OR 6.34, 95%CI 1.86-21.65), HIV infection (OR 2.99, 95%CI 1.16-7.70), grunting (OR 2.64, 95%CI 1.04-6.73), and digital clubbing (OR 10.75, 95%CI 1.21-95.56). PCP is a common and life-threatening cause of severe pneumonia in Mozambican children. Mother-to-child HIV transmission prevention should be strengthened. Better diagnostic tools are needed. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.cmi.2015.07.011 |
It is part of: | Clinical Microbiology and Infection, 2015, vol. 21, num. 11, p. 1018.e9–1018.e15 |
URI: | http://hdl.handle.net/2445/99513 |
Related resource: | http://dx.doi.org/10.1016/j.cmi.2015.07.011 |
ISSN: | 1198-743X |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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