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Title: Novel multimetabolite prediction of walnut consumption by a urinary biomarker model in a free-living population: the PREDIMED Study
Author: Garcia Aloy, Mar
Llorach, Rafael
Urpí Sardà, Mireia
Tulipani, Sara
Estruch Riba, Ramon
Martínez-González, Miguel Ángel, 1957-
Corella Piquer, Dolores
Fitó Colomer, Montserrat
Ros Rahola, Emilio
Salas Salvadó, Jordi
Andrés Lacueva, Ma. Cristina
Keywords: Marcadors bioquímics
Cromatografia de líquids d'alta resolució
Cuina (Nous)
Cuina mediterrània
Malalties cardiovasculars
Biochemical markers
High performance liquid chromatography
Cooking (Nuts)
Mediterranean cooking
Cardiovascular diseases
Issue Date: 3-Jul-2014
Publisher: American Chemical Society
Abstract: The beneficial impact of walnuts on human health has been attributed to their unique chemical composition. In order to characterize the dietary walnut fingerprinting, spot urine samples from two sets of 195 (training) and 186 (validation) individuals were analyzed by an HPLC-q-ToF-MS untargeted metabolomics approach, selecting the most discriminating metabolites by multivariate data analysis (VIP ≥ 1.5). Stepwise logistic regression analysis was used to design a multimetabolite prediction biomarker model. The global performance of the model and each included metabolite in it was evaluated by receiver operating characteristic curves, using the area under the curve (AUC) values. Dietary exposure to walnuts was characterized by 18 metabolites, including markers of fatty acid metabolism, ellagitannin-derived microbial compounds, and intermediate metabolites of the tryptophan/serotonin pathway. The predictive model of walnut exposure included at least one compound of each class. The AUC (95% CI) for the combined biomarker model was 93.4% (90.1-96.8%) in the training set and 90.2% (85.9-94.6%) in the validation set. The AUCs for individual metabolites were ≤85%. As far as we know, this is the first study proposing a combination of biomarkers of walnut exposure in a population under free-living conditions, as considered in epidemiological studies examining associations between diet and health outcomes.
Note: Versió postprint del document publicat a:
It is part of: Journal of Proteome Research, 2014, vol. 13, num. 7, p. 3476-3483
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ISSN: 1535-3893
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Medicina)

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