Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/109123
Title: Urinary 1H-NMR metabolomic fingerprinting reveals biomarkers of pulse consumption related to energy metabolism modulation in a subcohort from the PREDIMED study.
Author: Madrid Gambin, Francisco J.
Llorach, Rafael
Vázquez Fresno, Rosa
Urpí Sardà, Mireia
Almanza-Aguilera, Enrique
Garcia Aloy, Mar
Estruch Riba, Ramon
Corella, Dolores
Andrés Lacueva, Ma. Cristina
Keywords: Llegums
Metabòlits
Ressonància magnètica nuclear
Orina
Marcadors bioquímics
Legumes
Metabolites
Nuclear magnetic resonance
Urine
Biochemical markers
Issue Date: 9-Jan-2017
Publisher: American Chemical Society
Abstract: Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils and beans), spot urine samples from a subcohort from the PREDIMED study were stratified, using a validated food frequency questionnaire. Non-pulse consumers (≤ 4 g/day of pulse intake) and habitual pulse consumers (≥ 25 g/day of pulse intake) were analysed using a 1H-NMR metabolomics approach combined with multi- and univariate data analysis. Pulse consumption showed differences through 16 metabolites coming from (i) choline metabolism, (ii) protein-related compounds, and (iii) energy metabolism (including lower urinary glucose). Stepwise logistic regression analysis was applied to design a combined model of pulse exposure, which resulted in glutamine, dimethylamine and 3-methylhistidine. This model was evaluated by receiver operating characteristic curve (AUC > 90% in both training and validation sets). The application of NMR-based metabolomics to pulse exposure highlighted new candidates for biomarkers of pulse consumption, the role of choline metabolism and the impact on energy metabolism, generating new hypotheses on energy modulation. Further intervention studies will confirm these findings.
Note: Versió postprint del document publicat a: https://doi.org/10.1021/acs.jproteome.6b00860
It is part of: Journal of Proteome Research, 2017, vol.
Related resource: https://doi.org/10.1021/acs.jproteome.6b00860
URI: http://hdl.handle.net/2445/109123
ISSN: 1535-3893
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Medicina)

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