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http://hdl.handle.net/2445/128081
Title: | Slamf6 negatively regulates autoimmunity |
Author: | Wang, Ninghai Keszei, Marton Halibozek, Peter J. Yigit, Burcu Engel Rocamora, Pablo Terhorst, Cox |
Keywords: | Malalties autoimmunitàries Cèl·lules T Autoimmune diseases T cells |
Issue Date: | Dec-2016 |
Publisher: | Elsevier B.V. |
Abstract: | The nine SLAM family (Slamf) receptors are positive or negative regulators of adaptive and innate immune responses, and of several autoimmune diseases. Here we report that the transfer of Slamf6-/- B6 CD4+ T cells into co-isogenic bm12 mice causes SLE-like autoimmunity with elevated levels of autoantibodies. In addition, significantly higher percentages of Tfh cells and IFN-γ-producing CD4+ cells, as well as GC B cells were observed. Interestingly, the expression of the Slamf6-H1 isoform in Slamf6-/- CD4+ T cells did not induce this lupus-like phenotype. By contrast, Slamf1-/- or Slamf5-/- CD4+ T cells caused the same pathology as WT CD4+ T cells. As the transfer of Slamf [1+6]-/- or Slamf [1+5+6]-/- CD4+ T cells induced WT levels of autoantibodies, the presence of Slamf1 was requisite for the induction of increased levels of autoantibodies by Slamf6-/- CD4+ T cells. We conclude that Slamf6 functions as an inhibitory receptor that controls autoimmune responses. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.clim.2016.06.009 |
It is part of: | Clinical Immunology, 2016, vol. 173, p. 19-26 |
URI: | http://hdl.handle.net/2445/128081 |
Related resource: | https://doi.org/10.1016/j.clim.2016.06.009 |
ISSN: | 1521-6616 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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