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Title: Slamf6 negatively regulates autoimmunity
Author: Wang, Ninghai
Keszei, Marton
Halibozek, Peter
Yigit, Burcu
Engel Rocamora, Pablo
Terhorst, Cox
Keywords: Malalties autoimmunitàries
Cèl·lules T
Autoimmune diseases
T cells
Issue Date: Dec-2016
Publisher: Elsevier B.V.
Abstract: The nine SLAM family (Slamf) receptors are positive or negative regulators of adaptive and innate immune responses, and of several autoimmune diseases. Here we report that the transfer of Slamf6-/- B6 CD4+ T cells into co-isogenic bm12 mice causes SLE-like autoimmunity with elevated levels of autoantibodies. In addition, significantly higher percentages of Tfh cells and IFN-γ-producing CD4+ cells, as well as GC B cells were observed. Interestingly, the expression of the Slamf6-H1 isoform in Slamf6-/- CD4+ T cells did not induce this lupus-like phenotype. By contrast, Slamf1-/- or Slamf5-/- CD4+ T cells caused the same pathology as WT CD4+ T cells. As the transfer of Slamf [1+6]-/- or Slamf [1+5+6]-/- CD4+ T cells induced WT levels of autoantibodies, the presence of Slamf1 was requisite for the induction of increased levels of autoantibodies by Slamf6-/- CD4+ T cells. We conclude that Slamf6 functions as an inhibitory receptor that controls autoimmune responses.
Note: Versió postprint del document publicat a:
It is part of: Clinical Immunology, 2016, vol. 173, p. 19-26
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ISSN: 1521-6616
Appears in Collections:Articles publicats en revistes (Biomedicina)

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