Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/133320
Title: | Cooperative force generation of KIF1A Brownian motors |
Author: | Oriola Santandreu, David Casademunt i Viader, Jaume |
Keywords: | Proteïnes quinases Monòmers Protein kinases Monomers |
Issue Date: | 26-Jul-2013 |
Publisher: | American Physical Society |
Abstract: | KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions. |
Note: | Reproducció del document publicat a: https://doi.org/10.1103/PhysRevLett.111.048103 |
It is part of: | Physical Review Letters, 2013, vol. 111, num. 4, p. 048103 |
URI: | http://hdl.handle.net/2445/133320 |
Related resource: | https://doi.org/10.1103/PhysRevLett.111.048103 |
ISSN: | 0031-9007 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
629651.pdf | 281.46 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.