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Title: Recovery of Free Energy Branches in Single Molecule Experiments
Author: Junier, Ivan
Mossa, Alessandro
Mañosas Castejón, María
Ritort Farran, Fèlix
Keywords: Física de partícules
Particle physics
Issue Date: 19-Feb-2009
Publisher: American Physical Society
Abstract: We present a method for determining the free energy of coexisting states from irreversible work measurements. Our approach is based on a fluctuation relation that is valid for dissipative transformations in partially equilibrated systems. To illustrate the validity and usefulness of the approach, we use optical tweezers to determine the free energy branches of the native and unfolded states of a two-state molecule as a function of the pulling control parameter. We determine, within 0.6 k B T accuracy, the transition point where the free energies of the native and the unfolded states are equal.
Note: Reproducció del document publicat a:
It is part of: Physical Review Letters, 2009, vol. 102, num. 7, p. 070602
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ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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