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http://hdl.handle.net/2445/159357
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DC Field | Value | Language |
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dc.contributor.author | Lavi, Ido | - |
dc.contributor.author | Meunier, Nicolas | - |
dc.contributor.author | Voituriez, Raphaël | - |
dc.contributor.author | Casademunt i Viader, Jaume | - |
dc.date.accessioned | 2020-05-08T10:39:47Z | - |
dc.date.available | 2020-05-08T10:39:47Z | - |
dc.date.issued | 2020-02-06 | - |
dc.identifier.issn | 1539-3755 | - |
dc.identifier.uri | http://hdl.handle.net/2445/159357 | - |
dc.description.abstract | We introduce a minimal hydrodynamic model of polarization, migration, and deformation of a biologicalcell confined between two parallel surfaces. In our model, the cell is driven out of equilibrium by an activecytsokeleton force that acts on the membrane. The cell cytoplasm, described as a viscous droplet in the Darcyflow regime, contains a diffusive solute that actively transduces the applied cytoskeleton force. While fairlysimple and analytically tractable, this quasi-two-dimensional model predicts a range of compelling dynamicbehaviours. A linear stability analysis of the system reveals that solute activity first destabilizes a globalpolarization-translation mode, prompting cell motility through spontaneous symmetry breaking. At higheractivity, the system crosses a series of Hopf bifurcations leading to coupled oscillations of droplet shape andsolute concentration profiles. At the nonlinear level, we find traveling-wave solutions associated with uniquepolarized shapes that resemble experimental observations. Altogether, this model offers an analytical paradigmof active deformable systems in which viscous hydrodynamics are coupled to diffusive force transducers. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Physical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1103/PhysRevE.101.022404 | - |
dc.relation.ispartof | Physical Review E, 2020, vol. 101, num. 2, p. 022404 | - |
dc.relation.uri | https://doi.org/10.1103/PhysRevE.101.022404 | - |
dc.rights | (c) American Physical Society, 2020 | - |
dc.source | Articles publicats en revistes (Física de la Matèria Condensada) | - |
dc.subject.classification | Cèl·lules | - |
dc.subject.classification | Dinàmica molecular | - |
dc.subject.classification | Dinàmica de fluids | - |
dc.subject.other | Cells | - |
dc.subject.other | Molecular dynamics | - |
dc.subject.other | Fluid dynamics | - |
dc.title | Motility and morphodynamics of confined cells | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 699509 | - |
dc.date.updated | 2020-05-08T10:39:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
Files in This Item:
File | Description | Size | Format | |
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699509.pdf | 2.62 MB | Adobe PDF | View/Open |
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