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http://hdl.handle.net/2445/164099
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DC Field | Value | Language |
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dc.contributor.author | Tulipani, Sara | - |
dc.contributor.author | Palau Rodríguez, Magalí | - |
dc.contributor.author | Miñarro Alonso, Antonio | - |
dc.contributor.author | Cardona, Fernando | - |
dc.contributor.author | Marco Ramell, Anna | - |
dc.contributor.author | Zonja, Bozo | - |
dc.contributor.author | López de Alda, Miren | - |
dc.contributor.author | Muñoz-Garach, Araceli | - |
dc.contributor.author | Sànchez, Àlex (Sànchez Pla) | - |
dc.contributor.author | Tinahones, Francisco J. | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.date.accessioned | 2020-06-03T07:55:07Z | - |
dc.date.available | 2020-06-03T07:55:07Z | - |
dc.date.issued | 2016-10-05 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | http://hdl.handle.net/2445/164099 | - |
dc.description.abstract | Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=-0.56, p=0.0003; lysoPC C18:1: R=-0.61, p=0.0001; lysoPC C18:2 R=-0.64, p<0.0001]. Several amino acids were biomarkers of risk of diabetes onset associated to obesity. For instance, glutamate significantly associated with fasting insulin [R=0.5, p=0.0019] and HOMA-IR [R=0.46, p=0.0072], while glycine showed negative associations [fasting insulin: R=-0.51, p=0.0017; HOMA-IR: R=-0.49, p=0.0033], and the branched chain amino acid valine associated to prediabetes and insulin resistance in a BMI-independent manner [fasting insulin: R=0.37, p=0.0479; HOMA-IR: R=0.37, p=0.0468]. Minority sphingolipids including specific [dihydro]ceramides and sphingomyelins also associated with the prediabetic insulin resistant state, hence deserving attention as potential targets for early diagnosis or therapeutic intervention. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.cca.2016.10.005 | - |
dc.relation.ispartof | Clinica Chimica Acta, 2016, vol. 463, p. 53-61 | - |
dc.relation.uri | https://doi.org/10.1016/j.cca.2016.10.005 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Diabetis no-insulinodependent | - |
dc.subject.classification | Resistència a la insulina | - |
dc.subject.classification | Espectrometria de masses | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Fenotip | - |
dc.subject.classification | Metabolòmica | - |
dc.subject.other | Obesity | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Non-insulin-dependent diabetes | - |
dc.subject.other | Insulin resistance | - |
dc.subject.other | Mass spectrometry | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Phenotype | - |
dc.subject.other | Metabolomics | - |
dc.title | Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 664841 | - |
dc.date.updated | 2020-06-03T07:55:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
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664841.pdf | 1.67 MB | Adobe PDF | View/Open |
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