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Title: Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
Author: Ruiz-Iglesias, Patricia
Estruel Amades, Seila
Camps i Bossacoma, Mariona
Massot Cladera, Malen
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
Keywords: Exercici
Cèl·lules K
Sistema immunitari
Estrès oxidatiu
Rates (Animals de laboratori)
Killer cells
Immune system
Oxidative stress
Rats as laboratory animals
Issue Date: 1-May-2020
Publisher: MDPI
Abstract: Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive e ects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the e ect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alteration.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2020, vol. 12, num. 5, p. E1291
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
Articles publicats en revistes (Bioquímica i Fisiologia)

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