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Title: | Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons |
Author: | Urrea Zazurca, Laura Segura Feliu, Miriam Masuda-Suzukake, Masami Hervera Abad, Arnau Pedraz López, Lucas García Aznar, José Manuel Vila, Miquel Samitier i Martí, Josep Torrents Serra, Eduard Ferrer, Isidro (Ferrer Abizanda) Gavín Marín, Rosalina Hagesawa, Masato Río Fernández, José Antonio del |
Keywords: | Alfa-sinucleïna Prions Alpha-synuclein Prions |
Issue Date: | 1-Mar-2018 |
Publisher: | Springer |
Abstract: | The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils. |
Note: | Reproducció del document publicat a: https://doi.org/10.1007/s12035-017-0451-4 |
It is part of: | Molecular Neurobiology, 2018, vol. 55, num. 3, p. 1847-1860 |
URI: | http://hdl.handle.net/2445/172791 |
Related resource: | https://doi.org/10.1007/s12035-017-0451-4 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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UrreaL.pdf | Original Article | 18.32 MB | Adobe PDF | View/Open |
UrreaL_Err.pdf | Erratum | 271.06 kB | Adobe PDF | View/Open |
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