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Title: Direct detection of molecular intermediates from first-passage times
Author: Thorneywork, Alice L.
Gladrow, J.
Qing, Yujia
Rico Pastó, Marc
Ritort Farran, Fèlix
Bayley, Hagan
Kolomeisky, Anatoly B.
Keyser, U.F.
Keywords: Microfluídica
Cinètica química
Chemical kinetics
Issue Date: 1-Apr-2020
Publisher: American Association for the Advancement of Science
Abstract: All natural phenomena are governed by energy landscapes. However, the direct measurement of this fundamen-tal quantity remains challenging, particularly in complex systems involving intermediate states. Here, we uncover key details of the energy landscapes that underpin a range of experimental systems through quantitative analysis of first-passage time distributions. By combined study of colloidal dynamics in confinement, transport through a biological pore, and the folding kinetics of DNA hairpins, we demonstrate conclusively how a short-time, power-law regime of the first-passage time distribution reflects the number of intermediate states associated with each of these processes, despite their differing length scales, time scales, and interactions. We thereby establish a powerful method for investigating the underlying mechanisms of complex molecular processes.
Note: Reproducció del document publicat a:
It is part of: Science Advances, 2020, vol. 6, num. 18, p. eaaz4642
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ISSN: 2375-2548
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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