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Title: Innovative strategies to treat skin wounds with mangiferin: fabrication of transferosomes modified with glycols and mucin
Author: Allaw, Mohamad
Pleguezuelos Villa, Maria
Manca, Maria Letizia
Caddeo, Carla
Aroffu, Matteo
Nacher, Amparo
Díez Sales, Octavio
Ruiz Sauri, Amparo
Escribano Ferrer, Elvira
Fadda, Anna Maria
Manconi, Maria
Keywords: Malalties de la pell
Skin diseases
Issue Date: 16-Apr-2020
Publisher: Future Medicine
Abstract: im: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico-chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed in vivo. Conclusion: Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions.
Note: Reproducció del document publicat a:
It is part of: Nanomedicine, 2020, vol. 15 , num. 17, p. 1671-1685
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ISSN: 1743-5889
Appears in Collections:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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