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Title: Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol
Author: Domínguez López, Inés
Parilli-Moser, Isabella
Arancibia Riveros, Camila
Tresserra i Rimbau, Anna
Martínez González, Miguel Angel
Ortega Azorín, Carolina
Salas Salvadó, Jordi
Castañer, Olga
Lapetra, José
Arós, Fernando
Fiol, Miquel
Serra Majem, Lluís
Pintó, Xavier
Gómez Gracia, Enrique
Ros, Emilio
Lamuela Raventós, Rosa Ma.
Estruch, Ramon
Keywords: Àcid tàrtric
Malalties cardiovasculars
Tartaric acid
Cardiovascular system--Diseases
Issue Date: 22-Aug-2021
Publisher: MDPI AG
Abstract: Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 μg/mg (-5.54, -0.71), p-value = 0.016 and -3.03 μg/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2021, vol. 13, num. 8, p. 2883
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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