Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/22228
Title: | 3-Hydroxybutyrate coinfused with noradrenaline decreases resulting plasma levels of noradrenaline in Wistar rats |
Author: | Cañas, Xavier Sanchis, D. Gómez, G. Casanovas, J.M. Artigas Pérez, Francesc Fernández López, José Antonio Remesar Betlloch, Xavier Alemany, Marià, 1946- |
Keywords: | Metabolisme Nutrició Rates (Animals de laboratori) Metabolism Nutrition Rats as laboratory animals |
Issue Date: | 1997 |
Publisher: | Company of Biologists Ltd. |
Abstract: | Pentobarbital-anaesthetized male Wistar rats were infused with 6microgkg-1min-1 of noradrenaline. The infusion was supplemented with 8.5 mgkg-1min-1 of D-3-hydroxybutyrate (3-OHB) for 15 min in order to determine its effect on the adrenergic response of the rat. Plasma levels of noradrenaline rose to a plateau of approximately 50 nmoll-1 with infusion. In the group infused with noradrenaline alone, noradrenaline levels were maintained for 1h. Supplementation with 3-OHB induced a decrease in plasma noradrenaline level that was inversely correlated with 3-OHB level. Aortic and interscapular brown adipose tissue temperatures increased with noradrenaline infusion, but the rise was arrested by 3-OHB; replacing 3-OHB with glucose had no effect. Infusion of saline, glucose or 3-OHB in the absence of noradrenaline did not induce a rise in temperature in either tissue. Blood 3-OHB concentration increased to 1.2 mmoll-1 during 3-OHB infusion, decreasing rapidly at the end of infusion. Blood glucose levels increased with noradrenaline infusion; the presence of high 3-OHB levels decreased glucose concentration. The effects observed were transient and dependent on 3-OHB concentration; these effects may help explain most of the other effects of noradrenaline described here. The role of 3-OHB as a regulator of adrenergic responses seems to be part of a complex fail-safe mechanism which prevents wasting. |
Note: | Reproducció del document publicat a: http://jeb.biologists.org/content/200/20/2641.abstract |
It is part of: | Journal of Experimental Biology, 1997, vol. 200, p. 2641-2646 |
URI: | http://hdl.handle.net/2445/22228 |
ISSN: | 0022-0949 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
137320.pdf | 166.72 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.