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Title: Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.
Author: Sala Vila, Aleix
Harris, William S.
Cofán Pujol, Montserrat
Pérez-Heras, Ana Maria
Pintó Sala, Xavier
Lamuela Raventós, Rosa Ma.
Covas Planells, María Isabel
Estruch Riba, Ramon
Ros Rahola, Emilio
Keywords: Dieta
Malalties cardiovasculars
Factors de risc en les malalties
Àcids grassos omega-3
Cardiovascular diseases
Risk factors in diseases
Omega-3 fatty acids
Issue Date: Aug-2011
Publisher: Cambridge University Press
Abstract: The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
Note: Reproducció del document publicat a:
It is part of: British Journal of Nutrition, 2011, vol. 106, num. 3, p. 425-431
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ISSN: 0007-1145
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Podologia)

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