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http://hdl.handle.net/2445/69557
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DC Field | Value | Language |
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dc.contributor.author | Vázquez Fresno, Rosa | - |
dc.contributor.author | Llorach, Rafael | - |
dc.contributor.author | Urpí Sardà, Mireia | - |
dc.contributor.author | Khymenets, Olha | - |
dc.contributor.author | Bulló, Mònica | - |
dc.contributor.author | Corella Piquer, Dolores | - |
dc.contributor.author | Fitó Colomer, Montserrat | - |
dc.contributor.author | Martínez-González, Miguel Ángel, 1957- | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.date.accessioned | 2016-02-17T15:44:23Z | - |
dc.date.available | 2016-02-17T15:44:23Z | - |
dc.date.issued | 2014-08-11 | - |
dc.identifier.issn | 1573-3882 | - |
dc.identifier.uri | http://hdl.handle.net/2445/69557 | - |
dc.description.abstract | The development of robust biomarkers of consumption would improve the classification of participants with regard to their dietary exposure. In addition, validation of them in free-living individuals remains an important challenge. The aim of this study is to assess wine intake biomarkers using an NMR metabolomic approach to measure the utility of these biomarkers in a wine interventional study (WIS, n = 56) and also to evaluate them in a free-living individuals (PREDIMED study, n = 91). Nine metabolites showed a significantly higher presence in urinary excretion in WIS after wine intake: five food metabolome metabolites (tartrate, ethyl glucuronide [EtG], 2,3-butanediol, mannitol, and ethanol); one related to the endogenous response to wine exposure (3-methyl-2-oxovalerate) and three unidentified compounds. Receiver operating characteristic (ROC) curve for each single metabolite were evaluated and exhibited areas under the curves (AUC) between 67.4 and 86.3 % when they were evaluated individually. Then, a logistic regression model was fitted to generate a combined-biomarkers model using these metabolites. The model generated which included tartrate-EtG, showed an AUC of 90.7 % in WIS. Similarly, the AUC in the PREDIMED study was 92.4 %. Results showed that a model combining tartrate-EtG is more useful for evaluating exposure to wine than single biomarkers, both in interventional studies and epidemiological data. To our knowledge, this is the first time that a combined-biomarker model using an NMR platform in wine biomarkers' research has been generated and reproduced in a free-living population. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science + Business Media | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1007/s11306-014-0735-x | - |
dc.relation.ispartof | Metabolomics, 2014, vol. 11, num. 4, p. 797-806 | - |
dc.relation.uri | http://dx.doi.org/10.1007/s11306-014-0735-x | - |
dc.rights | (c) Springer Science + Business Media, 2014 | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Vi | - |
dc.subject.classification | Ressonància magnètica nuclear | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Nutrició | - |
dc.subject.classification | Metabòlits | - |
dc.subject.other | Wine | - |
dc.subject.other | Nuclear magnetic resonance | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Nutrition | - |
dc.subject.other | Metabolites | - |
dc.title | An NMR-based metabolomics approach reveals a combined-biomarkers model in a wine interventional trial with validation in free-living individuals of the PREDIMED study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 647357 | - |
dc.date.updated | 2016-02-17T15:44:23Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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647357.pdf | 769.12 kB | Adobe PDF | View/Open |
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